Exhibit 32.1

Written Statement of the Chief Executive Officer and Chief Financial Officer

Pursuant to 18 U.S.C. §1350

Solely for the purposes of complying with 18 U.S.C. §1350, I, the undersigned Chief Executive Officer of 22nd CENTURY GROUP, INC. (the “Company”), hereby certify, to the best of my knowledge, that the quarterly report on Form 10-Q of the Company for the quarter ended June 30, 2011 (the “Report”) fully complies with the requirements of Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 and that the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.
 
 
Date: August 15, 2011
 
 
 
/s/ Joseph Pandolfino
 
Joseph Pandolfino
 
Chief Executive Officer
   
 
Date: August 15, 2011
 
 
 
/s/ C. Anthony Rider
 
C. Anthony Rider
 
Chief Financial Officer