1. Facilitating Smoking Cessation With Reduced Nicotine Cigarettes

ClinicalTrials.gov Identifier:  NCT02796391

Sponsor:  H. Lee Moffitt Cancer Center and Research Institute

Collaborator:  James and Esther King Biomedical Research Program

2. Novel Approaches to Reducing Tobacco Related Harm

ClinicalTrials.gov Identifier:  NCT02600273

Sponsor:  Duke University

Collaborator:  National Institute of Allergy and Infectious Diseases (NIAID)

3. Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use

ClinicalTrials.gov Identifier:  NCT02870218

Sponsor:  Rose Research Center, LLC

Collaborators:  National Institutes of Health (NIH) and Food and Drug Administration (FDA)

4. Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers

ClinicalTrials.gov Identifier:  NCT02599571

Sponsor:  Duke University

Collaborators:  Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Food and Drug Administration (FDA), and University of Pittsburgh

5. Evaluation of Very Low Nicotine Content Cigarettes in Adolescent Smokers

ClinicalTrials.gov Identifier:  NCT02587312

Sponsor:  Brown University

Collaborator:  National Cancer Institute (NCI)

6. Manipulating Tobacco Constituents in Female Menthol Smokers

ClinicalTrials.gov Identifier:  NCT02048852

Sponsor:  University of Connecticut Health Center

Collaborator:  National Institute on Drug Abuse (NIDA)

7. Manipulating Tobacco Constituents in Male Menthol Smokers

ClinicalTrials.gov Identifier:  NCT02592772

Sponsor:  University of Connecticut Health Center

Collaborator:  National Institute on Drug Abuse (NIDA)

8. Project 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age Women

ClinicalTrials.gov Identifier:  NCT02250534

Sponsor:  University of Vermont

Collaborators:  National Institute on Drug Abuse (NIDA) and Johns Hopkins University

9. Project 1, Study 2: The Combined Impact of Nicotine Replacement and Spectrum Cigarettes

ClinicalTrials.gov Identifier:  NCT02301325

Sponsor:  University of Pittsburgh

10. Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers

ClinicalTrials.gov Identifier:  NCT02250664

Sponsor:  University of Vermont

Collaborators:  National Institute on Drug Abuse (NIDA) and Johns Hopkins University

11. Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders

ClinicalTrials.gov Identifier:  NCT02232737

Sponsor:  Brown University

Collaborator:  University of Vermont

12. Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status

ClinicalTrials.gov Identifier:  NCT01928719

Sponsor:  Milton S. Hershey Medical Center

Collaborator:  George Washington University

13. Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders

ClinicalTrials.gov Identifier:  NCT01928758

Sponsor:  Milton S. Hershey Medical Center

Collaborator:  National Institute on Drug Abuse (NIDA)

14. Strengthening Instrumental Extinction to Prevent Smoking Relapse (VLNCCue)

ClinicalTrials.gov Identifier:  NCT02538042

Sponsor:  Francis McClernon

Collaborators:  National Institutes of Health (NIH) and National Institute on Drug Abuse (NIDA)

15. Switching to Reduced Oxidant or Nicotine Content Cigarettes in Smokers

ClinicalTrials.gov Identifier:  NCT02415270

Sponsor:  Milton S. Hershey Medical Center

Collaborators:  Food and Drug Administration (FDA), National Institutes of Health (NIH), and National Institute on Drug Abuse (NIDA)

16. Very-Low Nicotine Cigarettes and Non-Daily Smokers

ClinicalTrials.gov Identifier:  NCT02228824

Sponsor:  University of Pittsburgh

Collaborator:  National Cancer Institute (NCI)

17. Very Low Nicotine Cigarettes in Smokers With Schizophrenia

ClinicalTrials.gov Identifier:  NCT02019459

Sponsor:  Brown University

Collaborators:  National Institute on Drug Abuse (NIDA) and University of Pittsburgh

18. Very Low-Nicotine Cigarettes in Smokers With SUD

ClinicalTrials.gov Identifier:  NCT01989507

Sponsor/Collaborator:  Brown University

19. Neuroimaging Reward, Behavioral Treatment, and Smoking Cessation

ClinicalTrials.gov Identifier:  NCT02927847

Sponsor:  Maggie M. Sweitzer, PhD

Collaborator:  National Institute on Drug Abuse (NIDA)

20. Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Marketplace:  Experiment 1

ClinicalTrials.gov Identifier:  NCT02951143

Sponsor:  Virginia Polytechnic Institute and State University

21. Concomitant Use of Very Low Nicotine Content Cigarettes and e-Cigarettes

ClinicalTrials.gov Identifier:  NCT02964182

Sponsor:  M.D. Anderson Cancer Center

Collaborator:  National Institute on Drug Abuse (NIDA)

22. Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers (NicRed)

ClinicalTrials.gov Identifier:  NCT02989038

Sponsor:  Duke University

Collaborator:  National Institute on Drug Abuse (NIDA)

23. Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder (RedNic)

ClinicalTrials.gov Identifier:  NCT02990455

Sponsor:  Battelle Memorial Institute

24. Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day

ClinicalTrials.gov Identifier:  NCT03060083

Sponsor:  University of Vermont

25. A Study to Assess Changes in Cigarette Consumption During a Switch to Very Low Nicotine Cigarettes

ClinicalTrials.gov Identifier: NCT03571724

Sponsor:  22nd Century Group, Inc.

Collaborator:  Celerion

26. Evaluation of the Abuse Liability of Very Low Nicotine (VLNC) Cigarettes

ClinicalTrials.gov Identifier:  NCT03559751

Sponsor:  22nd Century Group, Inc.

Collaborator: Vince & Associates Clinical Research, Inc.

27. Evaluation of Abuse Liability of Very Low Nicotine (VLNC) Mentholated Cigarettes

ClinicalTrials.gov Identifier:  NCT03559725

Sponsor:  22nd Century Group, Inc.

Collaborator: Vince & Associates Clinical Research, Inc.