Due to our extraordinary ability to grow tobacco across a wide spectrum of nicotine levels, 22nd Century Group was chosen to be a subcontractor for a government contract between RTI International (“RTI”) and the National Institute on Drug Abuse (“NIDA”), which is part of the National Institutes of Health (“NIH”), to supply to NIDA variable nicotine research cigarettes (8 different nicotine levels from very low to high encompassing 22 brand styles with different tar yields in both regular and menthol).

In August 2010, we met with officials from NIDA, FDA, RTI, the National Cancer Institute and the Centers for Disease Control and Prevention to design these important research cigarettes. Under the Company’s trademark “SPECTRUM,” the government research cigarettes were then purchased by NIDA for distribution to researchers across the country.

As of December 31, 2014, we have delivered approximately 17.5 million SPECTRUM research cigarettes to NIDA.

Though separate from the SPECTRUM research cigarettes program, we were also chosen to be a subcontractor for a government contract between RTI and the U.S. FDA to supply very low nicotine (“VLN”) fine cut tobacco to the FDA in the 4th quarter of 2013.

On July 7, 2014, we entered into a new Teaming Agreement with RTI under which we agreed to work with RTI on a potential new subcontract to supply NIDA with additional SPECTRUM research cigarettes pursuant to a new contract between RTI and NIDA.

22nd Century receives many requests, including from parties in various countries around the world, for cigarettes with varying nicotine levels. 22nd Century only supplies SPECTRUM to RTI, however, the Company can supply other tobacco cigarettes with specific nicotine content levels (from very low, approximately 0.50 mg/g to high, approximately 35 mg/g) to other researchers. If you are an accredited research organization interested in learning more about research cigarettes, please click on “Contact Us” and a Company representative will respond to your inquiry. For immediate assistance, please telephone the Company.